Preparation of a new immunosuppressant, 4-5-bis(aminomethyl)acridine.

نویسندگان

  • F K Hess
  • P B Stewart
چکیده

4,5-Bis(aminomethyl)acridine, useful as an immunosuppressant, was prepared in 31% overall yield by the reaction of acridine with N-(hydroxymethyl)phthalimide and subsequent decomposition with excess 6 N HCl. The drug was found to produce a suppression of the humoral antibody response comparable to several known immunosuppressive agents.

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عنوان ژورنال:
  • Journal of medicinal chemistry

دوره 18 3  شماره 

صفحات  -

تاریخ انتشار 1975